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Number of immunogenic pathogens/polysaccharides in vaccines over the past 100 years.
| Number of Proteins | Protein and Polysaccharides | |||
|---|---|---|---|---|
| Vaccine | 1900 | 1960s | 1980s | 2000s |
| Smallpox | −200 | −200 | ||
| Diphtheria | 1 | |||
| Tetanus | 1 | 1 | 1 | |
| Whole-cell pertussis | −3000 | −3000 | ||
| Acellular pertussis | 2-5 | |||
| Poliomyelitis | 15 | 15 | 15 | |
| Measles | 10 | 10 | ||
| Mumps | 9 | 9 | ||
| Haemophilus influenzae | 2 | |||
| Hepatitis B | 1 | |||
| Varicella | 69 | |||
| Pneumococcus | 8 |
Source: Aronson [25].
