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Schematic illustration of the genetic construct carried by the invasion plasmid of ShigETEC. LTB is fused to ST via a GPGP (GlyPro) linker (blue). ST is detoxified by an N12S mutation (red). Expression is driven by the LTA promoter and halted by the LTB termination sequence. The fusion gene is expressed as a 3× tandem repeat. The construct also expresses infA as a separate gene with intrinsic promoter and terminator sequences.
