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. 2020 Dec 2;8(4):720. doi: 10.3390/vaccines8040720

Figure 3.

Figure 3

Increased protein expression of carcinoembryonic antigen (CEA) and biliary glycoprotein (BGP) from cancerous and corresponding normal tissues from patients with CRC were compared to normal colon from patients without colon cancer. (a) Whole tissue extracts from colon cancer (CRC) subjects and normal (N) subjects (included in this figure are four samples shown in Figure 1a with an additional sample making a total of five) were subjected to Western blot analysis using specific antibodies to CEA and BGP. Equal loading was confirmed with β-actin. A representative blot is shown for five normal subjects and five CRC subjects. (b) Densitometric values are expressed as fold increase of the ratio of CEA/β-actin (mean± SEM) from 10 CRC and 10 normal patients, * p-value < 0.007. (c) Densitometric values are expressed as a fold increase of the ratio of BGP/β-actin (mean± SEM) from 10 CRC and 10 normal patients, * p-value < 0.005. As shown in (a) the CRC patients exhibited increased protein expression of BGP and CEA compared to normal subjects.