Table 1.
Physicochemical characterization of LCP-1 loaded nanoparticles.
| Formulation | Negative Polymer | Positive Polymer | Particle Size (nm) | PDI | Zeta Potential (mV) | Mass Ratio * |
|---|---|---|---|---|---|---|
| Lip-1 | alginate | TMC | 231 ± 1 | 0.176 ± 0.02 | 33.8 ± 1.7 | 10:6:10 |
| PEC-1 | alginate | TMC | 237 ± 4 | 0.199 ± 0.01 | 29.3 ± 1.5 | 10:4:8 |
| PEC-2 | chondroitin sulfate | TMC | 227 ± 2 | 0.133 ± 0.01 | 27.2 ± 0.2 | 10:5:10 |
| PEC-3 | dextran | TMC | 182 ± 1 | 0.193 ± 0.01 | 31.9 ± 0.6 | 10:2.5:8 |
| PEC-4 | hyaluronic acid | TMC | 199 ± 4 | 0.235 ± 0.01 | 29.6 ± 0.5 | 10:8:8 |
| PEC-5 | heparin | TMC | 206 ± 4 | 0.177 ± 0.01 | 29.5 ± 0.4 | 10:3:8 |
PDI: polydispersity index, TMC: trimethyl chitosan. * Mass ratio = LCP-1: negative polymer: TMC.