Table 1.
The putative CFEM proteins in Paracoccidioides spp. Genomes *.
| Species a | Gene ID b | Product Description c | CFEM (E-Value) d |
GPI Modification Site Prediction? e |
SignalP f | SecretomeP g |
|---|---|---|---|---|---|---|
| P. lutzii | PAAG_04763 | Hypothetical protein | 2.0 × 10−8 | None | Yes | - |
| PAAG_11627 | Hypothetical protein | 2.8 × 10−13 | None | Yes | - | |
| PAAG_05158 | Rbt5 # | 3.3 × 10−15 | Yes | Yes | - | |
| PAAG_02225 | Csa1 # | 5.2 × 10−12 | None | Yes | - | |
| PAAG_00918 | Hypothetical protein | 5.5 × 10−11 | None | Yes | - | |
| P. brasiliensis | PADG_11659 | Hypothetical protein | 1.5 × 10−11 | None | - | - |
| PADG_05363 | Csa1 # | 1.5 × 10−11 | None | Yes | - | |
| PADG_02506 | Hypothetical protein | 1.7 × 10−8 | None | Yes | - | |
| PADG_03909 | Hypothetical protein | 2.1 × 10−8 | Yes | Yes | - | |
| PADG_06374 | Hypothetical protein | 3.6 × 10−13 | None | - | Yes | |
| PADG_05000 | Rbt5 # | 4.5 × 10−15 | Yes | Yes | - | |
| P. americana | PABG_12009 | Hypothetical protein | 1.6 × 10−11 | None | Yes | - |
| PABG_00115 | Hypothetical protein | 1.7 × 10−8 | None | Yes | - | |
| PABG_01323 | Hypothetical protein | 2.4 × 10−8 | Yes | Yes | - | |
| PABG_04599 | Rbt51 # | 4.5 × 10−15 | Yes | Yes | - |
* The search for probable CFEM proteins in the genomes of Paracoccidioides was carried out using the online tool available at https://fungidb.org/fungidb/ (genes; sequence analysis; protein motif pattern). The term used in the search was CFEM. a Paracoccidioides species with genomes available in the FungiDB database. b Access code of the predicted CFEM-containing sequences. c Annotation available on FungiDB. d Confidence score of the prediction for CFEM domain presence. e Site prediction for GPI anchor modification. The prediction was performed by the online tool big-PI Predictor available at http://mendel.imp.ac.at/gpi/gpi_server.html. f Classical secretion prediction performed by the online tool SignalP 4.0 available at http://www.cbs.dtu.dk/services/SignalP-4.0/. g Non-classical secretion prediction performed by the online tool SecretomeP 2.0 available at http://www.cbs.dtu.dk/services/SecretomeP/. # Names assigned to the sequences as suggested by Bailão et al. (2014) [27].