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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Matrix Biol. 2020 Jan 23;89:43–58. doi: 10.1016/j.matbio.2020.01.001

Figure 7. A proposed working model for PGC1α-mediated metastasis suppression.

Figure 7.

In normal or high basal PGC1α expressing RCC cells, PGC1α induces miR-29a expression which in turn suppresses COL mRNA levels. Decreased COL expression by the PGC1α /miR-29a axis inhibits DDR1/ERK signaling thereby leading to SNAIL degradation. Loss of PGC1α results in stabilization of the prometastatic factors SNAIL1/2.