Table 1.

Most potent fungicidal compounds.

Compounds	Target	MFC	Ref.
Identified by virtual screening
CaCS02	Chorismate synthase	32 µg/mL	[65]
ZINC4559339	Isocitrate lyase	7.3–15.6 µg/mL	[66]
Oxadiazol LMM5	Thioredoxin reductase	1–32 μg/mL	[67]
Oxadiazol LMM11	Thioredoxin reductase	8–16 μg/mL	[67]
F3307-0100	Thioredoxin reductase	16.9 µM	[68]
HS7 (Zinc15967722)	Homoserine dehydrogenase	32 μg/mL	[69]
HS9 (Zinc2123137)	Homoserine dehydrogenase	8 μg/mL	[69]
Identified by drug repositioning
Vistusertib	Phosphatidylinositol 3-kinase TOR2	1.0–4.2 μM	[43]
Mebendazole	Tubulin beta chain	13.2–26.4 μM	[43]
Butoconazole	Lanosterol 14-alpha demethylase	0.001–0.002 µM	[43]
Luliconazole	Lanosterol 14-alpha demethylase	0.0013–0.0026 µM	[43]
ENMD-2076	Serine/threonine-protein kinase	7.4–14.8 µM	[43]
Plant derivatives
Hyptis ovalifolia/Argentilactone	Isocitrate lyase	4.5–36 μg/mL	[47]
Eugenia uniflora/oenothein B	Beta-glucana sintase	125–500 μg/mL	[70]
Schinus terebinthifolius/Schinol	ND	7.5–125 μg/mL	[71]
Baccharis dracunculifolia/Caryophyllene oxide	ND	125–250 μg/mL	[52]
Annona cornifolia	ND	2–250 µg/mL	[72]
Copaifera langsdorffii	ND	62.5 µg/mL	[37]
Fungal derivatives
Candida albicans/Farnesol	Cytoplasmic degeneration	30 µM	[58]
Aspergillus felis/Cytochalasin E	Cell wall	7.2 µM	[55]

MFC—minimum fungicidal concentration; ND—not determined.