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. 2020 Dec 3;11:522. doi: 10.1186/s13287-020-02024-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Physical properties of PEG/SF/HAp scaffolds. A SEM images (a and b) and FITC staining images (c and d) of the scaffolds prepared by unidirectional freezing. (a and c) Longitudinal sections parallel to the freezing direction. (b and d) Cross-sections perpendicular to the freezing direction (scale bar = 200 μm). B Diagram showing compression using a dynamic mechanical analyzer (DMA). C Original stress-strain curves of the scaffold. D Stress-strain curves (colorful) and fitted straight lines (red, just display one) from 5 to 15% strain. E Young’s modulus of the scaffolds with different concentration of hydroxyapatite (HAp). F Swelling kinetics of the scaffolds prepared with different proportions of HAp. G Fourier-transform infrared (FTIR) spectra of pure PEG, silk fibroin (SF), hydroxyapatite (HAp), and PEG/SF/HAp scaffolds (25, 50, 75, and 100 mg). H Thermogravimetric analysis (TGA) curve comparisons of PEG/SF/HAp scaffolds with different proportions of HAp. I X-ray diffraction (XRD) analysis of PEG/SF/HAp scaffolds