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. Author manuscript; available in PMC: 2020 Dec 3.
Published in final edited form as: Annu Rev Microbiol. 2020 Jun 5;74:21–37. doi: 10.1146/annurev-micro-020518-120107

Figure 1. CRISPR-Cas adaptive immunity and structurally determined anti-CRISPRs (Acrs).

Figure 1.

Homodimeric Acr-associated (Aca) proteins (pink) regulate Acr (red triangles) expression by binding to an upstream inverted repeat. Most suppressors of class 1 (left) and 2 (right) immune systems target the crRNA-guided surveillance and block DNA binding or nuclease activation.