Table 2.
List of some of the IONPs investigated for their protein corona composition. Only significantly enriched proteins are listed.
| Iron Oxide Nanoparticle | Physical Identity | Synthetic Identity (Surface Coating) | Biological Fluid | Biological Identity |
|---|---|---|---|---|
| IONP@Glu [100] | Fe3O4 | Poly(maleic anhydride-alt-1-octadecene)-EDC-glucose | Serum protein | Protein AMBP Coagulation factor XI Fibrinogen beta chain C4b-binding protein α-like Profilin-1 |
| IONP@PEG [100] | Fe3O4 | Poly(maleic anhydride-alt-1-octadecene)-EDC-PEG | Serum protein | Actin, aortic smooth muscle Keratin, type I cytoskeletal 10 Keratin, type II cytoskeletal 7 Lysozyme C Fructose-biphosphate aldolase |
| IONP@PMAO [100] | Fe3O4 | Poly(maleic anhydride-alt-1-octadecene) | Serum protein | Fibrinogen α-chain Tubulin α-4A chain Adenylyl cyclase-associated protein Macrophage migratory inhibitory factor Ectonucleotide Pyrophosphatase/phosphodiesterase family Member 2 |
| ZW-L1@PAA-USPIONs [104] | Fe3O4 | ZW-L1@PAA | 80% human serum | α-2-Macroglobulin precursor Apolipoprotein C-II precursor |
| ZW-L2@PAA-USPIONs [104] | Fe3O4 | ZW-L2@PAA | 80% human serum | Apolipoprotein C-II precursor Apolipoprotein A-I preprotein Apolipoprotein A-II preprotein Apolipoprotein A-IV precursor Serum albumin preprotein |
| ZW-L3@PAA-USPIONs [104] | Fe3O4 | ZW-L3@PAA | 80% human serum | Apolipoprotein B-100 precursor Vitronectin precursor Complement C3 precursor Serum albumin preprotein Apolipoprotein A-II preprotein |
| PAA@USPIONs [104] | Fe3O4 | PAA | 80% human serum | α-2-Macroglobulin precursor Apolipoprotein A-I preprotein Apolipoprotein C-III precursor Complement C3 precursor Apolipoprotein B-100 precursor |
| Rh-Citrate@ IONPs [105] | Fe3O4 | Rhodium citrate | Human blood serum | Human serum albumin Complement C5 A-Kinase anchor protein 13 Apolipoprotein A-I α-2-HS-glycoprotein |
| @IONPs/PVP @IONPs/PEG @IONPs [95] |
Fe3O4 | Polyvinylpyrrolidone (PVA) or polyethylene glycol (PEG) | Human plasma | 14-3-3-Protein β/α 14-3-3-Protein ε Protein kinase C inhibitor protein 1 78 kDa glucose-regulated protein (GRP-78) Actin, aortic smooth muscle (α-actin-2) |
| CSNP [97] | Fe3O4 | Silica | Human plasma | Fibrinogen b Fibrinogen g Fibrinogen a Vitronectin Histidine-rich glycoprotein |
| Nanomag-D@SPIO [97] | Fe3O4 | Dextran | Human plasma | Kininogen 1 microtubule-associated ser/thr Kinase-like Actin, beta Integrin, alpha 2b Pro-platelet basic protein |