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. 2020 Dec 3;10:21097. doi: 10.1038/s41598-020-78001-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Covalently closed circular DNA (cccDNA) epigenetic analysis under long-term Telbivudine treatment. Chromatin Immunoprecipitation analysis was performed using specific antibodies against H3K9me3, H3K27me3, H3K27Ac and H3K56Ac. Signal enrichment is expressed as the percentage of input cccDNA in untreated chronic hepatitis B comparative group (n = 7) (a) and Telbivudine-treated patients (n = 10) (b). Mann–Whitney U test was used to compare enrichment of specific antibodies vs the negative control (NoAb), alpha threshold = 0.05; * p < 0.05. cccDNA covalently closed circular DNA, NoAb negative control.