Table 2.

Brain regions showing a significant change in cortical thickness using automated surface-based cortical thickness analysis on INPH patients, compared with controls.

AAL label	Side	MNI coordinates (mm)			t value at peak vertex
		x	y	z
INPH < controls
Superior frontal gyrus, orbital part	L	− 13.3441	29.6287	− 20.4016	5.8802
Superior frontal gyrus, medial orbital	L	− 5.0920	31.7299	− 18.2721	3.8471
Gyrus rectus	R	12.3867	20.4167	− 14.6591	3.3969
	L	− 10.8271	29.4514	− 19.4515	5.8808
Superior temporal gyrus	R	45.6887	− 15.0709	− 1.3781	3.6985
Heschl gyrus	R	42.9363	− 19.3283	2.8886	3.4941
Middle temporal gyrus	R	55.1598	− 47.1271	− 5.0753	3.8506
	L	− 45.0293	1.8944	− 38.7950	4.6285
Inferior temporal gyrus	R	55.2281	− 49.7998	− 6.5307	4.0171
	L	− 41.4122	− 7.3936	− 44.2187	6.7110
Fusiform gyrus	L	− 35.1292	− 8.3738	− 44.0941	6.5411
Temporal pole: superior temporal gyrus	R	29.9650	3.8686	− 22.5338	3.7154
	L	− 31.0891	18.5766	− 39.7111	4.7930
Temporal pole: middle temporal gyrus	R	44.0117	11.9570	− 40.9585	3.4253
	L	− 33.7620	14.1866	− 39.9695	4.8589
Parahippocampal gyrus	R	20.1297	− 2.2402	− 33.4692	3.2492
	L	− 31.1506	− 2.0218	− 33.8223	4.4764
Insula	R	38.0828	4.7012	− 20.4475	3.4577
INPH > Controls
Precentral gyrus	R	16.8910	− 20.1658	75.2878	4.3277
	L	− 15.2051	− 27.7097	66.7879	5.2171
Postcentral gyrus	R	14.4552	− 37.1896	78.6438	6.2001
	L	− 9.1934	− 35.1024	78.7959	6.2651
Superior fontal gyrus, dorsolateral	R	12.2789	− 17.1400	69.0823	3.8645
	L	− 18.1194	− 4.4259	71.5490	4.6521
Middle frontal gyrus	R	33.9247	− 1.3880	54.3737	2.8145
	L	− 22.4661	8.4110	51.0797	3.8027
Supplementary motor area	R	10.0360	− 6.1336	68.4031	3.8893
	L	− 9.9315	− 4.9477	69.6016	4.7635
Paracentral lobule	R	7.3499	− 37.6936	78.7139	6.0228
	L	− 6.2403	− 40.6967	76.9401	6.3948
Superior parietal gyrus	R	14.0987	− 45.8018	76.6706	5.7830
	L	− 14.0987	− 45.8018	76.6706	5.5071
Angular gyrus	L	− 41.1132	− 57.6578	46.1287	3.2656
Precuneus	R	13.4494	− 44.3964	77.3371	5.8750
	L	− 13.4494	− 44.3964	77.3371	5.6610
Superior occipital gyrus	R	10.7603	− 87.4747	39.5211	3.2912
	L	− 12.3968	− 87.5935	39.8908	3.7520
Middle occipital gyrus	L	− 31.6555	− 65.4643	35.3210	2.7503
Cuneus	R	9.2163	− 84.9018	39.9622	3.3291
	L	− 11.8367	− 86.7401	40.6739	3.7759
Calcarine fissure and surrounding cortex	L	− 13.1142	− 70.4829	12.9637	3.3379

All reporting peak vertexes survived at the level of a false discovery rate P < 0.05.

INPH idiopathic normal-pressure hydrocephalus, AAL automated anatomic labeling, MNI Montreal Neurological Institute, L left, R right.