Table 2.

Primary and secondary outcomes

Key primary outcome	Key secondary outcomes
Mean change in the highest level of oxygenation (oxygen flow measured litre/min) in non-ventilated patients Mean change in lowest PaO2 in ventilated patients	Mortality (ICU or in-hospital) Duration of mechanical ventilation Duration of oxygen therapy Duration of hospitalisation Length of stay in ICU
Other secondary outcomes
Adverse drug events Acute kidney injury Acute liver injury Duration of vasopressor drugs Sequential organ failure assessment respiratory score	Clinical improvement based on an eight-point ordinal scale recommended in the document published by WHO R&D Blueprint ‘Novel Coronavirus COVID-19 Therapeutic Trial Synopsis’. Percentage of patients reporting each severity rating on an eight-point ordinal scale (time frame: day 14) Time to improvement in one category from admission using the eight-point ordinal scale (time frame: up to day 28) Mean change in the eight-point ordinal scale (time frame: up to day 28)

ICU, intensive care unit.