Table 1.
Baseline Characteristics of Patients with Non-Small-Cell Lung Cancer EGFR Mutation by Choroidal Metastasis Status
| Variables | All n = 83 | Choroidal metastases n = 7 | Non-choroidal metastases n = 76 | p-value |
|---|---|---|---|---|
| Age, years | ||||
| Mean | 69 | 56 | 70 | < 10−6 |
| Median (IQR) | 69 (60–80) | 57 (50–60) | 71 (61–80) | |
| Sex (%) | ||||
| Male | 37 (45) | 2 (29) | 35 (46) | 0.45 |
| Female | 46 (55) | 5 (71) | 41 (54) | |
| Smoking status (%) | ||||
| Current smoker | 4 (5) | 0 (0) | 4 (5) | 0.79 |
| Former smoker | 35 (42) | 4 (57) | 31 (41) | |
| Never smoker | 44 (53) | 3 (43) | 41 (54) | |
| Subtype of EGFR mutations (%) | ||||
| Exon 19 | 37 (44) | 3 (43) | 34 (45) | 1 |
| Exon 21 | 33 (40) | 3 (43) | 30 (39) | |
| Others | 13 (16) | 1 (14) | 12 (16) | |
| Co-mutation status (%) | ||||
| Yes | 52 (62) | 5 (71) | 47 (62) | 1 |
| No | 29 (35) | 2 (29) | 27 (35) | |
| Unknown | 2 (2) | 0 | 2 (3) | |
| Complex EGFR mutations (%) | ||||
| Yes | 11 (13) | 2 (29) | 9 (12) | 0.36 |
| No | 70 (84) | 5 (71) | 65 (85) | |
| Unknown | 2 (2) | 0 | 2 (3) | |
| TP53 co-mutation (%) | ||||
| Yes | 40 (48) | 4 (57) | 36 (47) | 0.76 |
| No | 41 (50) | 3 (43) | 38 (50) | |
| Unknown | 2 (2) | 0 | 2 (3) | |
IQR interquartile range
EGFR epidermal growth factor receptor