Table 1.

Solubility and dissolution efficiency (DE) of curcumin (CUR) crystals and various curcumin: hydroxypropyl β cyclodextrin solid dispersions prepared using grinding, freeze-drying, and common solvent evaporation methods (n = 3).

Sample	CUR:HPβCD Ratio (mol:mol)	Solubility (µg/mL)	DE (%)
CUR	-	0.03 ± 0.01	0.36 ± 0.02
GM11	1:1	0.89 ± 0.17	0.66 ± 0.12
GM12	1:2	1.25 ± 0.25	2.55 ± 0.13
GM14	1:4	2.55 ± 0.24	4.17 ± 0.26
GM18	1:8	6.61 ± 0.15	4.31 ± 0.10
FD11	1:1	0.27 ± 0.02	1.48 ± 0.27
FD12	1:2	0.54 ± 0.01	2.30 ± 0.31
FD14	1:4	1.61 ± 0.13	4.02 ± 0.46
FD18	1:8	5.23 ± 0.18	4.69 ± 0.60
CSE11	1:1	2.64 ± 0.11	2.82 ± 0.18
CSE12	1:2	3.08 ± 0.19	10.00 ± 0.45
CSE14	1:4	4.70 ± 0.29	31.27 ± 0.31
CSE18	1:8	14.16 ± 1.27	52.21 ± 0.75

CUR, Curcumin; HPβCD, Hydroxypropyl β cyclodextrin; GM, Ground mixture; FD, Freeze-drying; CSE, Common solvent evaporation; DE, Dissolution efficiency.