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. 2020 Dec 3;10:21018. doi: 10.1038/s41598-020-78056-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PYK2 mediated CTGF induction by TGF-β1 is independent of Smad activation. (A) Western blot of activated forms of Smad2 and Smad3 upon TGF-β1 stimuli in LX2 transfected with siRNAs of negative control, FAK, or PYK2 (n = 3). (B) IF of Smad2 in LX2 grown on glass and treated as indicated (n = 4). Scale bar: 50 μm. (C) Western blot of Smad2 and Smad3 (n = 2) and (D) qPCR of indicated genes (n = 3) in LX2 transfected with siRNAs of control, Smad2, Smad3, or Pyk2. Student's t-test; *p < 0.05, **p < 0.01, and ***p < 0.001.