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. 2020 Dec 3;11:6195. doi: 10.1038/s41467-020-19971-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a pDGVs in the WCM-UC cohort. The frequencies of pDGVs in the same gene in the TCGA-BLCA cohort are displayed as horizontal bar plots (right). b The odds ratio of pDGVs to rare synonymous variants in a gene set of 158 genes comparing WCM-UC and TCGA-BLCA cancer cohorts to ethnicity-matched SPARK non-cancer cohorts using a two-sided Fisher’s exact test. Each circle corresponds to one of four comparisons: WCM-EUR vs. SPARK-EUR, WCM-AJ vs. SPARK-AJ, TCGA-EUR vs. SPARK-EUR, or TCGA-AJ vs. SPARK-AJ. Each circle’s diameter indicates the number of individuals in either the WCM-UC (blue) or TCGA-BLCA (red) cohorts. The horizontal dotted line indicates the statistical significance threshold above which the p-values are less than 0.05. The vertical dotted line represents an odds ratio of 1. Data points on the right have a higher ratio of pDGVs to rare synonymous variants in the WCM-UC and TCGA-BLCA cohorts. c The odds ratio of pDGVs to rare synonymous variants in a gene set of 158 genes comparing TCGA pan-cancer cohorts (n = 7,839) to SPARK non-cancer cohort (n = 11,035) with a two-sided Fisher’s exact test. Each circle indicates the odds ratio (OR), and the error bars indicate the 95% confidence intervals (CI). The vertical dotted line represents an odds ratio of 1. Values to the right of this line represent a higher odds ratio of pDGVs to rare synonymous variants in respective cancer cohorts compared to the SPARK non-cancer cohort. Source data are provided as a Source Data file.