Fig. 2.

Quantification of α-synuclein, tau and amyloid-β pathology in multiple brain regions. a There was in increase in α-synuclein pathology in PDD compared to PDND cases in the hippocampus (Mann–Whitney U test, p = 0.015), entorhinal (Mann–Whitney U test, p = 0.015), and occipitotemporal cortex (Unpaired t test with Welch’s correction, p = 0.037). b There was no difference in tau pathology between groups in any region (Kruskal–Wallis test with Dunn’s correction for multiple comparisons, p > 0.05). c There were no between-group differences in amyloid-β pathology (Kruskal–Wallis test with Dunn’s correction for multiple comparisons, p > 0.05). AMG: Control n = 10, PDND n = 13, PDD n = 11, HIPP/ERC/OTC: Control n = 8, PDND n = 13, PDD n = 10, PFC: Control n = 13, PDND n = 15, PDD n = 7, PPC: Control n = 13, PDND n = 17, PDD n = 11. PDND Parkinson's disease no dementia, PDD Parkinson's disease dementia, AMG amygdala, HIPP Hippocampus, ERC entorhinal cortex, OTC occipitotemporal cortex, PFC prefrontal cortex, PPC posterior parietal cortex. *p < 0.05