Table 1.
Control and PD case demographics
| Control | PDND | PDD | p value | |
|---|---|---|---|---|
| N | 14 | 17 | 11 | – |
| Postmortem interval (h) | 64.1 (± 38.3) | 58.8 (± 28.1) | 61.5 (± 32.7) | 0.903 |
| Sex: % Male | 64.3% | 51.9% | 90.9% | 0.112 |
| Age at death | 79.8 (± 5.9) | 79.0 (± 8.1) | 81.8 (± 6.4) | 0.573 |
| Age at diagnosis | – | 66.9 (± 11.1) | 67.9 (± 9.7) | 0.803 |
| Disease duration at death (yr) | – | 12.1 (± 4.8) | 13.9 (± 6.4) | 0.396 |
| Interval from last assessment to death (yr) | – | 4.2 (± 3.3) | 3.9 (± 4.1) | 0.749 |
| Last Hoehn and Yahr score | – | 2.6 (± 0.7) | 2.9 (± 0.8) | 0.693 |
| Last UPDRS motor (on medication) | – | 30.6 (± 15.0) | 39.3 (± 9.9) | 0.117 |
| Last UPDRS total (on medication) | – | 50.2 (± 21.3) | 69.8 (± 16.9) | 0.021* |
| Last MMSE | – | 28.7 (± 1.2) | 20.6 (± 5.1) | < 0.0001**** |
| Change in MMSE per year | – | 0.21 (± 0.64) | − 1.46 (± 1.34) | < 0.0001**** |
Continuous variables were compared using One-way ANOVA (between Control, PDND and PDD) or Mann–Whitney U test (between PDND and PDD). Categorical variables (sex) were compared using the χ2 test. UPDRS Unified Parkinson’s Disease Rating Scale, MMSE Mini-Mental State Examination, PDND Parkinson's disease no dementia, PDD Parkinson's disease dementia. The values represent the mean (± SD)
*p < 0.05, ****p < 0.0001