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. 2020 Dec 3;10:21133. doi: 10.1038/s41598-020-78077-9

Table 2.

The synthesis of N-arylated cyproheptadinederivatives.

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Compound ID R1 R2 R3 R4 R5 Docking score Ligand efficiency
6a H COOH CH3 H H − 11.506 − 0.371
6b H CH3 COOH H H − 15.324 − 0.494
6c H H COOH H H − 15.568 − 0.519
6d NO2 H COOH H H − 12.220 − 0.370
6e H COOH H H H − 11.569 − 0.386
6f COOH H H H H − 8.404 − 0.280
8a NH2 H COOH H H − 12.994 − 0.419
8b H NH2 H COOH H − 14.352 − 0.463