Table 1.

Case Scenarios Relevant to ZIKV Likely to Be Encountered by Health Professionals Serving Children with Developmental Disabilities

Case Scenario	Questions to Be Answered
1. An infant presents to the clinic with known CZS	What is known about the developmental outcomes in these patients?  What co-occurring conditions are important to screen or monitor for?  What interventions are effective in this patient population?
2. An infant presents to the clinic with a history of microcephaly or other anomalies similar to CZS and unknown etiology	Can this infant be tested for CZS?  What other etiologies should I consider?
3. An infant or child presents to the clinic with possible prenatal exposure to ZIKV or documented prenatal ZIKV infection but typical appearance at birth	Is this infant at risk of developmental disabilities such as cerebral palsy, intellectual disability, and autism spectrum disorder?  How can one counsel the family on what to expect?  Can prenatal exposure to ZIKV cause more subtle disability (e.g., ADHD and learning disability or language delay)?
4. An infant or child presents to the clinic with postnatal exposure to ZIKV	Is this infant at risk of developmental disabilities?  How can one counsel the family on what to expect?

ADHD, attention-deficit hyperactivity disorder; CZS, congenital Zika syndrome; ZIKV, Zika virus.