Table 1. MICs of antibiotics and antimicrobial peptides against Pseudomonas aeruginosa strains.

The Mann-Whitney U test was used to compare the MIC values of C-DP, DP-C, and DP-C dimers with DP in P. aeruginosa. P-values less than 0.05 were considered statistically significant (* p < 0.05).

Strains of P. aeruginosaa	MIC (µg/mL)
	Antibiotics				Antimicrobial peptides
	Amikacin	Colistin	Meropenem	Ofloxacin	DP	C-DP*	DP-C*	DP-C Dimer*b
PAO-1	4	1	2	0.5	300	64	16	16
NCGM2.S1	128	1	>512	64	300	128	32	32
OCR1	8	1	8	2	>300	128	16	16
PAO4290	4	1	1	1	300	128	16	16

Notes.

^aP. aeruginosa strains used in this study were wild type PAO-1 (CLSI, 2018), the MDR clinical strain NCGM2.S1 (Miyoshi-Akiyama et al., 2011), the OprM overexpressing mutant OCR1 (Poole et al., 1996) and PAO4290 (Yoneyama et al., 1997) which expressed a wild-type level of MexAB-OprM.

^bGenerated by heating DP-C at 60 °C for 30 min to convert cysteine to cystine.