Table 2. MICs of antimicrobial peptides against strains of bacteria.
The Mann-Whitney U test was used to compare the MIC values of C-DP and DP-C with DP in species. P-values less than 0.05 were considered statistically significant (* p < 0.05).
| Strainsa | MIC (µg/mL) | Genes or mutations associated with drug resistance | ||||
|---|---|---|---|---|---|---|
| DP | C-DP | DP-C | β-lactamase(s) | 16S rRNA methylase | Colistin-resistance gene | |
| Acinetobacter baumannii* | ||||||
| ATCC15308 | 300 | 8 | 8 | |||
| IOMTU433 | 64 | 4 | 8 | blaNDM-1, blaOXA-23, blaPER-7 | ||
| NCGM237 | 128 | 4 | 8 | blaOXA-23 | armA | |
| NCGM253 | 128 | 4 | 8 | blaOXA-72 | ||
| Escherichia coli | ||||||
| ATCC 25922 | >300 | 16 | 8 | |||
| NCCHD1261-5 | 64 | 4 | 8 | blaNDM-5 | mcr-1 | |
| Klebsiella pneumoniae | ||||||
| ATCC 15380 | >128 | >128 | 128 | |||
| ATCC BAA-2146 | >128 | 16 | 16 | blaNDM-1 | ||
| Serratia marcescens | ||||||
| NBRC102204 | >256 | >256 | >256 | |||
| Staphylococcus aureus | ||||||
| ATCC 25923 | >128 | >128 | >128 | |||
Notes.
A. baumannii strains were wild-type strain ATCC 15308 and multi-drug resistant strains IOMTU433 (Tada et al., 2015) (GenBank accession no. AP014649), NCGM237 (Tada et al., 2015) (GenBank accession no. AP013357) and NCGM253 (Tada et al., 2015) (GenBank accession no. AB823544). E. coli strains were wild-type strain ATCC25922 and multi-drug resistant strain NCCHD1261-5 (Uchida et al., 2018). K. pneumoniae strains were multidrug-resistant strain ATCC15380 (Reading & Cole, 1977) and the penicillin resistant strain ATCC-BAA-2146, a resistance caused by the production of β-lactamase. The S. marcescens strain NBRC102204 and the S. aureus strain ATCC 25923 were wild-type strain.