Table 1.

 Patients and disease characteristics and their associations with the VEGFR2 rs1870377 genotype at the time of diagnosis (N = 494)

Characteristics	Overall		VEGFR2 rs1870377 genotype (N = 476)		P‐value
	N = 494	%	TT genotype	TA + AA genotype
Gender
Male	286	57.9	106	173	0.177
Female	208	42.1	63	134
Age (median, range)	57 (17–89)
≤60 years	289	58.5	90	189	0.078
60 years	205	41.5	79	118
Stage
I–II	223	45.1	72	143	0.404
III–IV	271	54.9	97	164
LDH
Normal	239	48.4	76	155	0.249
Elevated	267	51.4	93	152
ECOG PS
0–1	415	84.0	140	261	0.533
≥2	79	16.0	29	46
Extranodal sites
0–1	377	76.3	124	242	0.177
≥2	117	23.7	45	65
IPI score
0–2	325	65.8	108	207	0.437
3–5	169	34.2	61	100
B symptoms
Absent	365	73.9	129	222	0.340
Present	129	26.1	40	85
Bone marrow involvement
Absent	433	87.7	147	271	0.680
Present	61	12.3	22	36
Bulky disease
No	447	90.5	147	284	0.075
Yes	46	9.3	21	23
Primary extranodal disease
No	235	47.6	83	141	0.505
Yes	259	52.4	86	166

ECOG PS, Eastern Cooperative Oncology Group Performance Score; IPI, International Prognostic Index; LDH, lactate dehydrogenase.