Table 4.

 Multivariate analysis of factors prognostic for overall survival and progression‐free survival in patients with diffuse large B cell lymphoma

Variable	Overall survival			Progression‐free survival			Bootstrap probability
	HR	95% CI	P	HR	95% CI	P
Multivariate analysis including IPI score
B Sx	1.780	1.234–2.567	0.002	1.857	1.321–2.609	0.0001	0.964
VEGFR2 rs1870377	1.729	1.227–2.438	0.002	1.635	1.189–2.247	0.002	0.926
IPI
Low risk	1		0.0001	1		0.0001	0.215
Low–intermediate	1.870	1.131–3.091		1.500	0.949–2.373
High–intermediate	2.562	1.561–4.205		2.363	1.526–3.660
High	4.410	2.671–7.280		3.103	1.944–4.951
Multivariate analysis including IPI variables
Age >60 years	2.148	1.524–3.028	0.0001	1.925	1.403–2.640	0.0001	0.971
LDH >normal	1.843	1.235–2.748	0.003	1.851	1.286–2.666	0.001	0.974
Extranodal >1	1.564	1.081–2.264	0.018	1.457	1.030–2.060	0.033	0.859
B Sx	2.020	1.407–2.900	0.0001	2.035	1.459–2.838	0.0001	0.964
VEGFR2 rs1870377	1.645	1.165–2.324	0.005	1.565	1.137–2.153	0.006	0.926

95% CI, 95% confidence interval; HR, hazard ratio; IPI, International Prognostic Index; LDH, lactate dehydrogenase.