Figure 6.
Cell growth of activation‐induced cytidine deaminase (AID)‐positive transfectants. The AID‐positive transfectants showed low proliferation rates compared with the parental cells and vector‐only transfectant used as controls. Cells cultured for 12 h were pulsed with 0.5 mCi [3H]thymidine, then harvested onto glass filters after 24, 48, and 72 h. (A) Three AID‐positive clones from a patient with follicular lymphoma (FL), designated FL30, expressing different levels of AID showed damping of cell proliferation that was proportional to the expression level of the AID gene, compared with controls. (B) Similar results were obtained for AID‐positive clones from patient FL32.