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. 2020 Dec 3;17:369. doi: 10.1186/s12974-020-02043-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Intracranial injection of Theiler’s murine encephalomyelitis virus (TMEV) leads to acute behavioral seizures. a Cumulatively, 93.75% of the TMEV-infected animals exhibited at least one stage 3 or greater seizure during the twice daily (AM and PM) observation periods. Cumulative percentage of mice that experienced stage 3 or greater seizures listed on top of bars. b On any given day, the percentage of mice exhibiting a stage 3 or greater seizure ranged between 37 and 87% during any individual observation period. As half the total TMEV-infected mice (n = 16) were sacrificed after the observation period on 4 dpi, the number of mice observed from 5-7 dpi was reduced to n = 8. Number of seized and non-seized mice listed in bars. c The total numbers of seizures observed based on the modified Racine scale on each day during seizure monitoring show the seizure intensity increases over the course of the observation period. Number of seizures listed above bars