Table 1.
Baseline Demographics and Clinical Characteristics of Participants
| All Switchers (n = 972) | Suppressed at Switch (n = 691) | |
|---|---|---|
| Male sex, % | 81 | 82 |
| Age, years | 50 (45, 57) | 51 (46, 57) |
| Black race, % | 29 | 26 |
| Hispanic ethnicity, % | 19 | 19 |
| Body mass index, kg/m2 | 26.4 (23.5, 29.9) | 26.9 (23.7, 30.3) |
| Weight, kg | 79.1 (69.1, 91.7) | 79.9 (69.9, 93.3) |
| Body mass index category, % | ||
| Underweight | 2 | 1 |
| Normal | 37 | 34 |
| Overweight | 37 | 37 |
| Obese | 25 | 27 |
| Waist circumference, cm | 93.5 (86.0, 102.1) | 94.2 (86.9, 103.5) |
| Waist circumference elevated for sex,a % | 52 | 56 |
| Total cholesterol, mg/dL | 180 (156, 211) | 183 (159, 213) |
| HDL cholesterol, mg/dL | 43 (35, 53) | 45 (37, 55) |
| Triglycerides, mg/dL | 139 (97, 214) | 137 (96, 209) |
| LDL cholesterol, mg/dL | 103 (80, 126) | 105 (83, 129) |
| Fasting glucose, mg/dL | 90 (83, 100) | 91 (84, 102) |
| Hemoglobin A1c, % | 5.5 (5.2, 5.9) | 5.5 (5.2, 5.9) |
| History of diabetes prior to switch, % | 11 | 12 |
| History of smoking prior to switch, % | 58 | 57 |
| Current CD4+ T-cell count, cells/μL | 512 (321, 749) | 610 (439, 816) |
| Nadir CD4+ T-cell count ≤200 cells/μL, % | 59 | 54 |
| HIV-1 RNA prior to switch, copies/mL | 40 (39, 1,077) | … |
| ART regimen prior to switch, % | ||
| PI-based | 68 | 63 |
| NNRTI-based | 31 | 35 |
| Other | 5 | 2 |
| Main NRTI component prior to switch, % | ||
| ABC | 20 | 25 |
| TDF | 53 | 49 |
| TAF | 11 | 14 |
Data are presented as medians (interquartile range) or percentages. Values are at time of/prior to switch unless indicated.
Abbreviations: ABC, abacavir; ART, antiretroviral therapy; HDL, high-density lipoprotein; HIV, human immunodeficiency virus; HOMA-IR, homeostasis model assessment–insulin resistance; LDL, low-density lipoprotein; NNRTI, nonnucleoside reverse transcriptase inhibitor; NRTI, nucleoside/-tide reverse transcriptase inhibitor; PI, protease inhibitor; TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate.
aGreater than 94 cm for men and 80 cm for women.