Table 4.

Effect of Integrase Strand Transfer Inhibitor Weight Change on Fasting Lipid and Glucose Parameters

	HDL Cholesterol	LDL Cholesterol	Total Cholesterol	Triglycerides	Glucose
Change in lipid/glucose parameter (mg/dL) per 1-kg change in weight after INSTI switch	−0.14 [−.16, −.12] (<.001)	0.26 [.20, .32] (<.001)	0.36 [.29, .44] (<.001)	1.10 [.83, 1.37] (<.001)	0.06 [.02, .10] (.007)

Data are presented as B-estimates [95% CI] (P value). Reference values: female sex, black race, <40 years of age, no diabetes. Models were adjusted for time after INSTI switch, baseline lipid/glucose value, sex, race/ethnicity, age, nadir CD4⁺ T-cell count, proportion of time of viral suppressed, and history of diabetes.

Abbreviations: BMI, body mass index; CI, confidence interval; INSTI, integrase strand transfer inhibitor.