TABLE 1.
Characteristics of Randomized Controlled Trials (n = 403) Included in the Study
| Unit of randomization | |
| Individual | 397 (98.5) |
| Cluster | 6 (1.5) |
| Type of consent | |
| Informed | 403 (100.0) |
| Region of coordinating center | |
| North America | 147 (36.5) |
| Central and South America | 15 (3.7) |
| Australia | 10 (2.5) |
| Asia | 12 (3.0) |
| Europe | 219 (54.3) |
| Eligibility criteria | |
| Reported | 403 (100.0) |
| Recruitment | |
| Inpatient | 93 (23.1) |
| Ambulatory | 310 (76.9) |
| Type of intervention | |
| Health service | 49 (12.2) |
| Drug | 271 (67.2) |
| Device | 46 (11.4) |
| Surgery | 8 (2.0) |
| Exercise/rehabilitation | 29 (7.2) |
| Number of centers | |
| Single center | 172 (42.7) |
| Multicenter | 231 (57.3) |
| Type of follow-up | |
| Face-to-face | 392 (97.3) |
| Database | 11 (2.7) |
| Scope of trial | |
| National | 302 (74.9) |
| International | 101 (25.1) |
| Type of funding | |
| Public | 185 (45.9) |
| Industry | 163 (40.4) |
| Public and industry | 55 (13.6) |
| Gender of lead author | |
| Men | 340 (84.4) |
| Women | 63 (15.6) |
| Gender of senior author | |
| Men | 351 (87.1) |
| Women | 52 (12.9) |
| Gender of corresponding author | |
| Men | 357 (88.6) |
| Women | 46 (11.4) |
| Year of publication | |
| 2000–2003 | 127 (31.5) |
| 2004–2007 | 109 (27.0) |
| 2008–2011 | 47 (11.7) |
| 2012–2015 | 51 (12.7) |
| 2016–2019 | 69 (17.1) |
Values are n (%).