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. Author manuscript; available in PMC: 2020 Dec 3.
Published in final edited form as: J Med Chem. 2008 Jul 4;51(15):4834–4838. doi: 10.1021/jm800167u

Scheme 2. Synthesis of Compounds 14–17a.

Scheme 2.

a Reagents and conditions: (i) (CF3CO)2O, toluene, reflux, 4 h, 1 for 14, 2 for 15; (ii) KHCO3, MeOH, room temp. The definitions of X and Y are indicated in Chart 1.