Table 1.
Percentage of HepG2 Cell Deatha
| compd | 1 μM | 0.1 μM | 0.01 μM | 0.001 μM |
|---|---|---|---|---|
| OA | 0 | 0 | 0 | 0 |
| 18 | 0 | 0 | 0 | 0 |
| 8a | 67.41 | 13.68 | 10.07 | 0 |
| 8b | 100.00 | 93.50 | 13.34 | 1.70 |
| 8c | 98.16 | 56.35 | 10.96 | 2.60 |
| 8d | 95.63 | 67.96 | 17.32 | 2.70 |
| 8e | 74.53 | 13.01 | 8.51 | 0 |
| 8f | 0 | 0 | 0 | 0 |
| 11h | 0 | 0 | 0 | 0 |
| 14b | 0 | 0 | 0 | 0 |
| 16b | 89.21 | 55.11 | 6.67 | 0 |
Data shown are the average percentages of cell death induced by the compound at 24 h post-treatment from three independent experiments. Intragroup variations were less than 10% of the values presented. Treatment of the cells with the compound for a longer period did not increase its cytotoxicity. The other 23 synthesized compounds tested showed no cytotoxicity against HepG2 in our experimental system (data not shown).