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. Author manuscript; available in PMC: 2020 Dec 3.
Published in final edited form as: J Med Chem. 2008 Jul 4;51(15):4834–4838. doi: 10.1021/jm800167u

Table 1.

Percentage of HepG2 Cell Deatha

compd 1 μM 0.1 μM 0.01 μM 0.001 μM
OA 0 0 0 0
18 0 0 0 0
8a 67.41 13.68 10.07 0
8b 100.00 93.50 13.34 1.70
8c 98.16 56.35 10.96 2.60
8d 95.63 67.96 17.32 2.70
8e 74.53 13.01 8.51 0
8f 0 0 0 0
11h 0 0 0 0
14b 0 0 0 0
16b 89.21 55.11 6.67 0
a

Data shown are the average percentages of cell death induced by the compound at 24 h post-treatment from three independent experiments. Intragroup variations were less than 10% of the values presented. Treatment of the cells with the compound for a longer period did not increase its cytotoxicity. The other 23 synthesized compounds tested showed no cytotoxicity against HepG2 in our experimental system (data not shown).