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. 2020 Nov 10;95(19):e2666–e2674. doi: 10.1212/WNL.0000000000010733

Figure 4. Escitalopram over 4 weeks completely arrested individual plaque growth.

Figure 4

Six-month-old amyloid precursor protein (APP)/presenilin 1 (PS1) mice were treated with escitalopram at doses of 2.5 or 5 mg/kg per day or vehicle IP for 28 days (vehicle: n = 11 mice, 104 plaques; escitalopram 2.5 mg/kg: n = 5 mice, 40 plaques; escitalopram 5 mg/kg: n = 4 mice, 66 plaques) and imaged using 2-photon microscopy. (A) Representative multiphoton micrographs (20× magnification) of individual amyloid plaques in the cortex of APP/PS1 mice (before [0 days] and 28 days after treatment. P = plaque. (B) 5 mg/kg escitalopram and 10 mg/kg escitalopram attenuated the growth of preexisting plaques. (C) Escitalopram 5 mg/kg and escitalopram 10 mg/kg reduced the appearance of new plaques. All p values resulted from 1-way analysis of variance with Dunnett multiple comparison post statistical tests and statistical significance was set at *p < 0.05, **p < 0.01, and ***p < 0.001.