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. 2020 Sep 15;95(11):e1554–e1564. doi: 10.1212/WNL.0000000000010314

Figure 1. Association between years of education, APOE ε4 status, and their interaction on β-amyloid (Aβ) pathology.

Figure 1

Years of education (A, D), APOE ε4 status (B, E), and their interactive effects (C, F) on Aβ pathology in asymptomatic individuals with a parental history of sporadic Alzheimer disease (AD) (Presymptomatic Evaluation of Experimental or Novel Treatments for AD [PREVENT-AD], A–C) and presymptomatic autosomal dominant AD mutation carriers (Dominantly Inherited Alzheimer Network [DIAN], D–F). Raw data (i.e., unadjusted standardized uptake value ratio [SUVR]) are plotted. Solid lines represent estimated regression lines; dotted lines represent 95% confidence intervals. Statistical values were obtained using general linear models controlling for age, sex, and Mini-Mental State Examination, as well as mutation type and site in DIAN.