Figure 2. Voxelwise associations among years of education, APOE ε4 status, and β-amyloid (Aβ) pathology.

Visualization of the voxelwise association between Aβ pathology and years of education (A, C) and APOE ε4 status (B, D) in asymptomatic individuals with a parental history of sporadic Alzheimer disease (AD) (Presymptomatic Evaluation of Experimental or Novel Treatments for AD [PREVENT-AD]; A, B) and presymptomatic autosomal dominant AD mutation carriers (Dominantly Inherited Alzheimer Network [DIAN]; C, D). Statistical maps thresholded at p < 0.005 uncorrected with a minimum cluster size of 200.