Figure 3. Comparison of the association between education and β-amyloid (Aβ) pathology in Presymptomatic Evaluation of Experimental and Novel Treatments for AD (PREVENT-AD) vs Dominantly Inherited Alzheimer Network (DIAN).

Direct comparison of the effect of years of education on Aβ burden between individuals with a parental history of sporadic Alzheimer disease (AD) (PREVENT-AD) and presymptomatic autosomal dominant AD mutation carriers (DIAN) using standardized Centiloid values. Raw data (i.e., unadjusted standardized uptake value ratio) are plotted. Solid lines represent estimated regression lines; dotted lines represent 95% confidence intervals. Statistical values were obtained using general linear models controlling for age, sex, Mini-Mental State Examination, and APOE ε4 status.