Figure 2. Association with each prodromal feature comparing extreme quintiles of adherence to aMED diet pattern.

Cohort-specific and pooled multivariable-adjusted odds ratios for each of the 7 prodromal features comparing each the extreme quintiles of alternate Mediterranean diet (aMED) adherence at baseline and for cumulative average diet between 1986 and 2006. Models are adjusted for age in years at baseline and cohort-specific quintiles of caffeine intake, caloric intake, and physical activity, as well as smoking pack-year categories and body mass index categories. (A) Health Professionals Follow-up Study (HPFS), (B) Nurses' Health Study (NHS), and (C) pooled cohort. pRBD= probable REM sleep behavior disorder. ^aStatistically significant heterogeneity across cohorts. ^bMarginally statistically significant heterogeneity across cohort.