Figure 2. Association between speech-in-noise SRT and quartiles of AD-GRS (n = 80,074).

There was a significant trend (p = 0.04) for increasing quartile of Alzheimer disease genetic risk score (AD-GRS) and worse speech reception threshold(SRT) (positive change) on a continuous scale. However, only the fourth quartile had a significantly worse SRT than the first quartile of AD-GRS (reference group). Based on a linear regression of log SRT adjusted for age, sex, and 5 principal components to account for confounding by population stratification.