Figure 1.

(a) Moderate hyperthermic heating occurs in periablational zone and has been related with tumor cell activity [1]. This heating could affect either a tumor area outside the thermal coagulation zone (which is completely destroyed) or nearby micronodules. (b) Relation between percentage of living cells after heating and index Ω obtained from the Arrhenius damage model, which associates temperature with exposure time using a first-order kinetics relationship. Periablational zone was assumed to be between Ω=0.6 and Ω=2.1 (values derived from experimental data in [1], see text for details), while coagulation zone was defined by the Ω=4.6 contour, which represents 99% probability of cell death.