Fig. 1.

Y‐27632 does not rescue oral keratinocytes from senescence. (A, C) SA‐β‐Gal activity decreases after Y‐27632 treatment in both NOK805 (A) and D6 (C) senescent cells, but cells did not recapitulate cell growth. Scale bars are 50 μm. (B, D) p16 expression in senescent NOK805 (B) and D6 cells (D) does not change after Y‐27632. (E) SA‐β‐Gal quantification in senescent NOK805 and D6‐treated and nontreated cells. Data are shown as mean ± SEM. (F) Population doublings of senescent NOK805 and D6‐treated and nontreated cells. Data are shown as mean ± SEM. N = 3 independent experiments.