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. 2020 Dec 3;15(12):e0243268. doi: 10.1371/journal.pone.0243268

Table 3. Mortality and pneumonia among patients with COVID-19 according to the period between initial symptoms and clinical progression to COVID-19 suspicion (PISYCS).

Variable Mortality Pneumonia
All Patients (N = 65,500)
PISYCS (N) %* OR (95% CI) p-value %* OR (95% CI) p-value
< 24 Hours (9759) 5.2% 1.75 (1.55–1.98) <0.001 22.5% 1.49 (1.39–1.58) <0.001
1–3 Days (28331) 2.5% 1 1 14% 1 1
4–7 Days (20877) 3.6% 1.53 (1.37–1.70) <0.001 19.5 1.48 (1.41–1.56) <0.001
> 7 Days (6533) 4.1% 1.67 (1.44–1.94) <0.001 20.6% 1.57 (1.46–1.69) <0.001
“p value” <0.001 <0.001
SUBGROUP ANALYSIS
Positive Test (N = 13,842)        
PISYCS OR (95% CI) p-value OR (95% CI) p-value
< 24 Hours 2.11 (1.75–2.55) <0.001 1.66 (1.45–1.90) <0.001
1–3 Days 1 1 1 1
4–7 Days 1.42 (1.22–1.65) <0.001 1.69 (1.53–1.85) <0.001
> 7 Days 1.22 (1.00–1.49) 0.053 1.83 (1.62–2.07) <0.001
Negative Test (N = 43,419)        
PISYCS OR (95% CI) p-value OR (95% CI) p-value
< 24 Hours 1.55 (1.29–1.86) <0.001 1.58 (1.46–1.70) <0.001
1–3 Days 1 1 1 1
4–7 Days 1.00 (0.83–1.21) 0.967 1.10 (1.01–1.16) 0.038
> 7 Days 1.39 (1.10–1.81) 0.014 1.11 (1.00–1.24) 0.061
Test Result Pending (N = 8,239)        
PISYCS OR (95% CI) p-value OR (95% CI) p-value
< 24 Hours 1.41 (0.68–2.90) 0.357 0.80 (0.64–0.99) 0.043
1–3 Days 1 1 1 1
4–7 Days 1.22 (0.70–2.13) 0.484 2.03 (1.77–2.34) <0.001
> 7 Days 1.71 (0.78–3.74) 0.182 1.96 (1.57–2.44) <0.001

This Global Multiple Logistic Regression Model is adjusted for all demographic characteristics and comorbid conditions present in the patients. Adjustments for the group of all patients can be found in S1 and S2 Tables.

*Bivariate analysis between PISYCS vs. Mortality or Pneumonia.