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. 2020 Dec 3;15(12):e0243346. doi: 10.1371/journal.pone.0243346

Table 1. General and demographic characteristics from enrolled population.

Parameter Total Disease phenotype P-value (severe vs critical)
Severe Critical
Percentage (number) 52% (13/25) 48% (12/25) NA
Age (years) 35–75 38–75 35–67 0.1091
(51.2 ± 10.8)* (54.5 ± 10.0)* (47.5 ± 10.9)*
Gender 1.0000
Male (%) 64% (16/25) 61.5% (8/13) 66.7% (8/12)
Female (%) 36% (9/25) 38.5% (5/13) 33.3% (4/12)
Symptoms
Dyspnea 88% (22/25) 84.6% (11/13) 91.6% (11/12) 1.0000
Cough 84% (21/25) 76.9% (10/13) 91.6% (11/12) 0.5930
Fever 80% (20/25) 84.6% (11/13) 75.0% (9/12) 0.6447
Myalgia 56% (14/25) 61.3% (8/13) 50.0% (6/12) 0.6951
Fatigue 32% (8/25) 30.8% (4/13) 33.3% (4/12) 1.0000
Headache 24% (6/25) 23.1% (3/13) 25.0% (3/12) 1.0000
Nasal Congestion 16% (4/25) 7.7% (1/13) 25.0% (3/12) 0.3217
Anosmia 8% (2/25) 0% (0/13) 16.7% (2/12) 0.2200
Ageusia 8% (2/25) 0% (0/13) 16.7% (2/12) 0.2200
Nausea 4% (1/25) 7.7% (1/13) 0% (0/12) 1.0000
Odynophagia 4% (1/25) 0% (0/13) 8.3% (1/12) 0.4800
Hyporexia 4% (1/25) 7.7% (1/13) 0% (0/12) 1.0000
Rhinorrhea 4% (1/25) 7.7% (1/13) 0% (0/12) 1.0000
Days post symptoms onset
Hospital admission 2–14 (8.6 ± 3·0)* 2–14 (8.8 ± 3.5)* 5–14 (8.3 ± 2.6)* 0.6876
Fundus examination 10–64 10–22 14–64 0.0021
(23.9 ± 14.2)* (15.3 ± 3.5)* (33.25 ± 15.6)*
Past Medical History
Arterial Hypertension 60% (15/25) 53.9% (7/13) 66.7% (8/12) 0.6882
Diabetes 32% (8/25) 30.8% (4/13) 33.3% (4/12) 1.0000
Obesity 32% (8/25) 23.1% (3/13) 41.7% (5/12) 0.4110
None 24% (6/25) 30.8% (4/13) 16.7% (2/12) 0.6447
Asthma 4% (1/25) 7.7% (1/13) 0% (0/12) 1.0000
Cancer 4% (1/25) 7.7% (1/13) 0% (0/12) 1.0000
COPD 4% (1/25) 0% (0/13) 8.3% (1/12) 0.4800
Hypothyroidism 4% (1/25) 0% (0/13) 8.3% (1/12) 0.4800
Retinal changes 12% (3/25) 15.4% (2/13) 8.3% (1/12) 1.0000

COPD = Chronic Obstructive Pulmonary Disease

*Mean ± STD; NA: Not Applicable.