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. 2020 Dec 3;16(12):e1008449. doi: 10.1371/journal.pcbi.1008449

Fig 6. Predicted affinity-enhancing mutations for hACE2.

Fig 6

Analyzing the residue energetics of ACE2 orthologs suggests mutations that have the potential to enhance the affinity of hACE2 (white) to RBD (teal). The top panels shows our top-scoring hACE2:RBD model and its interactions (yellow cylinders) for four such sites: residues 24, 25, 30, and 387. The bottom panels show mutations in specific species, and the resulting new or enhanced interactions: Q24E in pangolin, A25V in dog, D30E in cow, and A387E in ferret. Some of these mutations are found in multiple ACE2 orthologs.