Table 8. Summary of neurological development variants.

Chr	rsID	Nearest Gene	Bayley Phenotype	Growth Phenotype	P-Val	N	Relevant Expression & effects of variants	Literature Reference
17	rs178850	RAB11FIP4	Adaptive	lambda	2.02E-08	428	Highly brain specific (7-10-fold higher than other tissues), affects neurofibroma growth, next to NF1 and OMG	Bartelt-Kirbach et al., 2009 [44]
1	rs6672510	PLD5	*	lambda	3.12E-08	1053	High expression in brain, then adrenal and ovary, previously associated with autism and multiple sclerosis.	Anney et al., 2010 [45], Baranzini et al., 2009 [46]
5	rs6878810	LHFPL2	Social-Emotional	alpha	1.13E-07	428	Genetic modifier of Parkinson's age of onset, new AD susceptibility locus	Hill-Burns et al., 2016 [25], Potkin et al., 2009 [26]
XY-PAR1	rs5949162	LOC107985677	Social-emotional	*	1.92E-07	227 (M)	high expression in brain and endometrium
1	rs584297	LOC105373115, (near STUM)	Adaptive	lambda	3.15E-07	428	STUM codes for highly brain specific, mechanosensory protein	Desai et al., 2014 [47]
1	rs525410	LAMC2	Social-Emotional	lambda	4.56E-07	428	LAMC1 is just upstream, highly placenta specific, LAMC2 is near NMNAT2, brain specific, cognitive traits candidate	Bi, et al., 2017 [48], Sun et al., 2008 [43]
8	rs7387693	MTMR7	Adaptive	*	9.54E-07	433	Highly brain specific, candidate for Creutzfeldt-Jacob risk, smoking cessation	Sanchez-Juan et al., 2012 [49]
12	rs1291359	HTR7P1	Adaptive	*	1.55E-07	433	Serotonin receptor pseudogene, SNP is in promoter region of HEBP1 (Immune system related)
8	rs11787410	CSMD1	Adaptive	lambda	8.84E-07	428	High brain and testis expression, linked to schizophrenia risk	Sakamoto et al., 2016 [50]
11	rs10769889	LMO1	Social-Emotional	alpha	8.88E-07	428	Pediatric neuroblastoma susceptibility candidate, expressed in adrenal, brain and skin	Oldridge et al., 2015 [51]
3	rs4955988	CACNA2D3	Adaptive	*	2.13E-06	433	highest expression in brain, next in adrenal, calcium channel subunit, role in regulating iron uptake	Baeza-Richer, Carlos et al. (2013) [52]
8	rs7462219	MTMR7	Adaptive	*	2.67E-06	433	Highly brain specific, candidate for Creutzfeldt-Jacob risk, smoking cessation	Sanchez-Juan et al., 2012 [49]
XY—PAR2	rs306875	SPRY3	Adaptive	linf	1.15E-06	223 (M)	Brain expression, Placental expression, autism candidate	Ning et al., 2015 [53]
9	rs4741967	SLC1A1	Social-Emotional	linf	1.21E-06	428	Glutamate transporter implicated in epilepsy, linked to OCD risk	Afshari et al., 2015 [54], Arnold, et al., 2006 [55]
22	rs5751491	LINC01639, just upstream of MPPED1	Adaptive	lambda	1.32E-06	428	Almost exclusively brain expressed, region linked to schizophrenia risk, bipolar disorder and brain malignancies	Chen et al., 2010 [56]
17	rs11658800	ELAC2	Language	*	2.48E-06	433	High expression in the brain tissues
16	rs2938729	CDH8	Language	linf	1.61E-06	428	Highly brain-specific
11	rs10833478	NELL1	Motor	*	3.41E-07	433	Brain and kidney specific, interacts with neural EGFL	Shen et al., 2016 [57]
14	rs7155811	TMEM260	Motor	*	2.17E-06	433	Implicated in pediatric neural development	Ta-Shma et al., 2017 [58]
3	rs7611656	TRANK1*	Adaptive	lambda	3.36E-06	428	High endometrial expression, bipolar candidate	Chen et al., 2013 [59], Ruderfer et al., 2014 [60]
14	rs11628108	C14orf177	Social-Emotional	*	1.56E-06	433	Testis expression, linked to late onset Alzheimer's	Kunkle et al., 2016 [61]
14	rs12434723	C14orf177	Social-Emotional	*	2.61E-06	433	Testis expression, linked to late onset Alzheimer's	Kunkle et al., 2016 [61]

Features of a collection of the genes linked to 22 SNPs that we have tied to the neurological traits, having p-values < 5x10^-6 and either: high brain levels of expression or specificity of expression, or published phenotypic effects related to neurological functions in human studies. The notation (M) in the N column indicates that the dependency was determined for male subjects only. TRANK1, marked with an asterisk, falls just below the p-value threshold so does not appear in Table 4.