Fig 5. Selective 5HT2A receptor antagonist improved thermal hyperalgesia in neuropathic pain model.
Plantar tests were performed before nerve ligation surgery, on test day 7 with vehicle, and on test day 8 with MDL 100907 administration (n = 8) (A). Paw withdrawal latencies were plotted for every test. Data are expressed as means ± SEM. Data are analyzed using two-way ANOVA followed by Bonferroni’s post hoc test and considered statistically significant at ****P < 0.0001 when comparing the sham and ligation groups (B).