Fig 6. Selective 5HT2A receptor antagonist improved quantity of sleep in neuropathic pain model.
EEG and EMG were recorded for 24 hours with administration of vehicle (test day 7) and MDL 100907 (test day 9) (A). The mean value per hour of wake, REM sleep, and non-REM sleep time are represented for sham (n = 7) and nerve ligation groups (n = 7). Data are expressed as means ± SEM. Data are analyzed using two-way ANOVA followed by Bonferroni’s post hoc test and considered statistically significant at ***P < 0.001, and ****P < 0.0001 when comparing all groups (B).