Fig 7. Selective 5HT_2A receptor antagonist improved quality of sleep in neuropathic pain model.

Distribution of EEG power density in each frequency during non-REM and REM sleep. Data are expressed as means only (A). Time changes of the normalized power density of δ wave are plotted every 3 hours in sham (n = 6) and nerve ligation (n = 5) mice. Data are expressed as means ± SEM (B). Data are analyzed using two-way ANOVA followed by Bonferroni’s post hoc test and considered statistically significant at *P < 0.05 when comparing the sham-vehicle and ligation-vehicle groups, ^#P < 0.05 when comparing the ligation-vehicle and ligation-MDL 100907 groups, and ⁺P < 0.05 when comparing the sham-amitriptyline and ligation-vehicle groups.