Fig 2. Tumor size and survival.
Animal numbers at start of study diet: SD = 9, SD+r0.4 = 3; SD +r4 = 5; KD = 9; KD+r0.4 = 4; KD+r4 = 4; Tumor size (A) was measured once a week. Volume (mm3) was calculated as 0.5 L x S2 (L and S is the longest and shortest dimensions). The sum of all visible tumor volumes in each mouse was used as its tumor volume, and each point represents tumor volumes from 3–9 mice. Longevity (B) was determined to the time a mouse became moribund. The blue and red lines are the data from SD and KD groups, respectively. r0.4 and r4 represents rapamycin at the dose 0.4 mg/kg and 4 mg/kg for 2 weeks, respectively.