Table 3. Unadjusted associations between sample characteristics and latent tuberculosis infection (LTBI) treatment.
Three treatment measures are examined: 1) level of isoniazid treatment completion, 2) completion of 6 months of isoniazid, and 3) the number of months of dispensed isoniazid (n = 662).
| Level of LTBI Treatment Completion | ≥6 Months of LTBI Treatment Completed | 3) Number of Months of Isoniazid Dispensed Within 1 Year of Initiation | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neither Regimen Completed: <6 Months (Row % or Mean) | ≥6 but <9 Months Complete (Row % or Mean) | ≥9 Months Complete (Row % or Mean) | ≥6 Months Complete (Row % or Mean) | Median # Months Dispensed | ||||||||||||||
| % or Mean | 95% Confidence Interval | % or Mean | 95% Confidence Interval | % or Mean | 95% Confidence Interval | p-value: 3 Completion Levels | 95% Confidence Interval | p-value: <6 vs. ≥6 Months Complete | 95% Confidence Interval | |||||||||
| Lower | Upper | Lower | Upper | Lower | Upper | % or Mean | Lower | Upper | Lower | Upper | p-value | |||||||
| Pre-Treatment Testing Pattern | ||||||||||||||||||
| One TST | 57.82% | 52.47% | 62.98% | 22.12% | 18.01% | 26.87% | 20.06% | 16.12% | 24.68% | 42.18% | 37.02% | 47.53% | 5 | 4 | 5 | |||
| One IGRA | 45.03% | 38.09% | 52.17% | 25.13% | 19.47% | 31.79% | 29.84% | 23.76% | 36.74% | 54.97% | 47.83% | 61.91% | 6 | 5 | 7 | |||
| One TST followed by one IGRA | 32.76% | 21.87% | 45.88% | 25.86% | 16.15% | 38.72% | 41.38% | 29.39% | 54.48% | 67.24% | 54.12% | 78.13% | 8 | 6 | 9 | |||
| Other pattern of multiple TSTs and/or IGRAs | 45.95% | 34.89% | 57.41% | 21.62% | 13.63% | 32.53% | 32.43% | 22.71% | 43.95% | <0.001 | 54.05% | 42.59% | 65.11% | 0.001 | 6 | 5 | 7 | <0.001 |
| Sex | ||||||||||||||||||
| Female | 52.23% | 47.04% | 57.38% | 22.91% | 18.83% | 27.56% | 24.86% | 20.64% | 29.62% | 47.77% | 42.62% | 52.96% | 5 | 5 | 6 | |||
| Male | 48.68% | 43.09% | 54.32% | 23.68% | 19.23% | 28.81% | 27.63% | 22.88% | 32.95% | 0.334 | 51.32% | 45.68% | 56.91% | 0.363 | 6 | 5 | 6 | 0.213 |
| Age Group | ||||||||||||||||||
| 0–14 | 42.05% | 32.14% | 52.64% | 25.00% | 17.01% | 35.15% | 32.95% | 23.90% | 43.48% | 57.95% | 47.36% | 67.86% | 7 | 6 | 8 | |||
| 15–29 | 52.20% | 44.91% | 59.39% | 24.73% | 18.98% | 31.54% | 23.08% | 17.50% | 29.78% | 47.80% | 40.61% | 55.09% | 5.5 | 4 | 6 | |||
| 30–44 | 55.98% | 48.70% | 63.01% | 22.83% | 17.31% | 29.48% | 21.20% | 15.86% | 27.73% | 44.02% | 36.99% | 51.30% | 5 | 4 | 6 | |||
| 45–64 | 48.08% | 41.34% | 54.89% | 21.63% | 16.54% | 27.78% | 30.29% | 24.40% | 36.90% | 0.064 | 51.92% | 45.11% | 58.66% | 0.144 | 6 | 5 | 7 | 0.032 |
| Census Region | ||||||||||||||||||
| Northeast | 52.38% | 45.60% | 59.08% | 19.05% | 14.27% | 24.95% | 28.57% | 22.85% | 35.08% | 47.62% | 40.92% | 54.40% | 5 | 4 | 6 | |||
| Midwest | 48.51% | 38.88% | 58.26% | 26.73% | 18.97% | 36.25% | 24.75% | 17.27% | 34.14% | 51.49% | 41.74% | 61.12% | 6 | 4 | 6 | |||
| South | 57.45% | 47.21% | 67.08% | 20.21% | 13.24% | 29.61% | 22.34% | 15.00% | 31.93% | 42.55% | 32.92% | 52.79% | 5 | 3 | 6 | |||
| West | 47.47% | 41.41% | 53.61% | 26.46% | 21.41% | 32.21% | 26.07% | 21.05% | 31.80% | 0.549 | 52.53% | 46.39% | 58.59% | 0.361 | 6 | 5 | 7 | 0.320 |
| Patient Location | ||||||||||||||||||
| Large Central Metro County (Urban) | 48.88% | 43.36% | 54.43% | 24.60% | 20.13% | 29.69% | 26.52% | 21.91% | 31.70% | 51.12% | 45.57% | 56.64% | 6 | 5 | 6 | |||
| Large Fringe Metro County (Suburban) | 52.96% | 46.78% | 59.06% | 20.16% | 15.65% | 25.58% | 26.88% | 21.76% | 32.70% | 47.04% | 40.94% | 53.22% | 5 | 4 | 6 | |||
| Any Smaller County | 50.00% | 40.06% | 59.94% | 27.08% | 19.10% | 36.89% | 22.92% | 15.55% | 32.44% | 0.797 | 50.00% | 40.06% | 59.94% | 0.623 | 6 | 4 | 6 | 0.570 |
| % of Households Under FPL in County | ||||||||||||||||||
| <15% | 46.79% | 41.77% | 51.88% | 23.80% | 19.74% | 28.39% | 29.41% | 25.00% | 34.25% | 53.21% | 48.12% | 58.23% | 6 | 5 | 7 | |||
| ≥15% | 55.56% | 49.75% | 61.22% | 22.57% | 18.09% | 27.78% | 21.88% | 17.46% | 27.04% | 0.014 | 44.44% | 38.78% | 50.25% | 0.026 | 5 | 4 | 6 | 0.023 |
| Insurance Type | ||||||||||||||||||
| HMO | 63.27% | 53.25% | 72.26% | 18.37% | 11.85% | 27.35% | 18.37% | 11.85% | 27.35% | 36.73% | 27.74% | 46.75% | 4 | 3 | 5 | |||
| POS | 49.68% | 45.18% | 54.19% | 24.95% | 21.24% | 29.06% | 25.37% | 21.64% | 29.50% | 50.32% | 45.81% | 54.82% | 6 | 5 | 6 | |||
| PPO | 41.76% | 32.03% | 52.17% | 19.78% | 12.79% | 29.31% | 38.46% | 29.00% | 48.89% | 0.004 | 58.24% | 47.83% | 67.97% | 0.010 | 6 | 5 | 8 | 0.006 |
| Supply of Isoniazid Received on Date of 1st Fill | ||||||||||||||||||
| < 2 month supply | 51.39% | 47.42% | 55.35% | 24.22% | 20.98% | 27.79% | 24.39% | 21.14% | 27.96% | 48.61% | 44.65% | 52.58% | 6 | 5 | 6 | |||
| ≥2 month supply | 41.18% | 28.48% | 55.17% | 11.76% | 5.33% | 23.99% | 47.06% | 33.76% | 60.79% | 0.015 | 58.82% | 44.83% | 71.52% | 0.161 | 6 | 4 | 9 | 0.004 |
| Period Regimen Started | ||||||||||||||||||
| 2011 Q3-4 | 55.63% | 47.34% | 63.63% | 26.06% | 19.47% | 33.93% | 18.31% | 12.75% | 25.58% | 44.37% | 36.37% | 52.66% | 5 | 4 | 6 | |||
| 2012 Q1-4 | 51.34% | 45.26% | 57.38% | 19.92% | 15.50% | 25.23% | 28.74% | 23.55% | 34.54% | 48.66% | 42.62% | 54.74% | 5 | 5 | 6 | |||
| 2013 Q1-4 | 48.02% | 41.56% | 54.54% | 25.11% | 19.88% | 31.18% | 26.87% | 21.49% | 33.04% | 51.98% | 45.46% | 58.44% | 6 | 5 | 6 | |||
| 2014 Q1 | 40.63% | 25.02% | 58.38% | 25.00% | 12.86% | 42.94% | 34.38% | 19.95% | 52.40% | 0.181 | 59.38% | 41.62% | 74.98% | 0.338 | 6 | 2 | 9 | 0.637 |
| State TB Rate per 100,000 | 3.93 | 3.78 | 4.08 | 3.91 | 3.67 | 4.15 | 3.81 | 3.59 | 4.03 | 0.451 | 3.86 | 3.70 | 4.02 | 0.560 | N/A | - | - | 0.807 |
| % Foreign Born in County | 20.61 | 19.33 | 21.89 | 20.76 | 18.66 | 22.86 | 21.78 | 19.84 | 23.72 | 0.516 | 21.30 | 19.88 | 22.73 | 0.667 | N/A | - | - | 0.269 |
| Count of Clinical Risk Factors* | ||||||||||||||||||
| None | 54.55% | 49.67% | 59.34% | 22.11% | 18.33% | 26.42% | 23.34% | 19.47% | 27.71% | 45.45% | 40.66% | 50.33% | 5 | 5 | 6 | |||
| 1 | 44.27% | 37.37% | 51.40% | 26.56% | 20.77% | 33.29% | 29.17% | 23.15% | 36.01% | 55.73% | 48.60% | 62.63% | 6 | 5 | 7 | |||
| 2 or more | 44.44% | 32.63% | 56.92% | 20.63% | 12.31% | 32.50% | 34.92% | 24.13% | 47.52% | 0.029 | 55.56% | 43.08% | 67.37% | 0.038 | 6 | 3 | 8 | 0.026 |
* Clinical risk factors included diabetes, tobacco use, a history or late effects of TB, contact with or exposure to TB, HIV, and immune-suppressive medication use.
Abbreviations
HIV: Human immunodeficiency virus
HMO: Health maintenance organization
IGRA: Interferon gamma release assay
N/A: Not applicable
POS: Place of service
PPO: Preferred provider organization
Q1: Quarter 1 of the calendar year
Q1-4: Quarters 1–4 of the calendar year (full year)
Q3-4: Quarters 3 and 4 of the calendar year
TB: Tuberculosis
TST: Tuberculin skin test