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. 2020 Nov 10;9:e52555. doi: 10.7554/eLife.52555

Table 1. SAR table for JK3/32 series showing compounds contributing directly.

Core oxindole scaffold for JK3/32 shown, indicating six R-groups (R1-R6) subjected to modification, as well as a position within the core structure (A).

Table 1—source data 1. JK series compound structures.
Activity vs gt1b p7 (J4-JFH1 HCV), 72 hr treatment
graphic file with name elife-52555-inf1.jpg
Compound R1 R2 R4 R5 R6 A EC50 (µM) CC50 (µM)
JK3-32 Bzl H OMe H H CH 0.184 ± 0.089 (n = 4) >100
JK3-42 Ph H OMe H H CH 0.932 ± 0.812
(n = 2)		 >4
JK3-38 H H OMe H H CH >4
(n = 2)		 >4
21-RS-7 Bzl H OMe H H N 1.34 ± 0.37
(n = 3)		 >4
21-RS-8 Bzl H H H H N 0.775 ± 0.700
(n = 2)		 >40
21-RS-9 Ph H OMe H H N >40
(n = 1)		 >40
1191–104 Bzl OMe H H H CH 11.33
(n = 1)		 >40
1191–112 Bzl H CN H H CH >4
(n = 1)		 13.3 ± 12.4
(n = 2)
1191–121 Bzl H OMe H F CH 0.40 ± 0.12
(n = 2)		 12.8
1191–120 graphic file with name elife-52555-inf2.jpg H OMe H H CH 1.42 ± 1.38
(n = 2)		 5.4 ± 4.4
(n = 2)
1191–124 graphic file with name elife-52555-inf3.jpg H OMe F H CH 0.32 ± 0.35
(n = 2)		 8.3 ± 3.9
(n = 2)
1191–106 graphic file with name elife-52555-inf4.jpg H OMe H H CH 11.58
(n = 1)		 >40
1191–137 graphic file with name elife-52555-inf5.jpg H OMe H H CH 2.30
(n = 1)		 12.5
1191–140 graphic file with name elife-52555-inf6.jpg H OMe H H CH 0.461
(n = 1)		 10.4
1191–141 graphic file with name elife-52555-inf7.jpg H F H H CH >1.26 >1.26
1191–146 graphic file with name elife-52555-inf8.jpg H graphic file with name elife-52555-inf9.jpg H H CH 2.48
(n = 1)		 >12.6
1191–125 graphic file with name elife-52555-inf10.jpg H H F H CH 0.209
(n = 1)		 12.9
1191–126 graphic file with name elife-52555-inf11.jpg H CN F H CH 3.76
(n = 1)		 >40
Additional compounds:
Compound Structure EC50 (µM) CC50 (µM)
21-RS-17 graphic file with name elife-52555-inf12.jpg 1.73 ± 1.68
(n = 2)		 >4
R21 graphic file with name elife-52555-inf13.jpg >40
(n = 6)		 >40